90ANITHYPERLIPIDEMIC ACTIVITY OF ETHANOLIC EXTRACT OF LIMONIA ACIDISSIMA ROOTS IN HIGH FAT DIET INDUCED HYPERLIPIDEMIC RATSThe present study was conducted to evaluate the antihyperlipidemic activity of ethanolic root extract of Limonia acidissima in high fat diet induced hyperlipidemia rats. The rats were divided into 5 groups of 6 animals each. The animals of all the groups except normal group were given a high cholesterol diet consisting of 2% cholesterol, 1% cholic acid and 2 ml coconut with standard pellet diet for 30 days. The first group served as normal control received 0.5% Carboxy Methyl Cellulose orally for 30 days. The second group served as hyperlipidemic control, was given High cholesterol diet while the third group was treated with et hanolic extract of Limonia acidissima root (200 mg/kg, p.o.), once a day for 30 days. The fourth group was treated with Atorvastatin suspension prepared with 0.5% CMC (10mg/kg; p.o.), once a day for 30 days. Hyperlipidemia was induced by high cholesterol diet consisting of 2% cholesterol, 1% cholic acid and 2 ml coconut oil with standard pellet diet for 30 days. On 31 st day the serum was subjected to various biochemical tests like Total Choleserol, Triglyceride, HDL -C, and LDL-C, VLDL-C. The results showed that there was significant decrease in Total Choleserol, Triglyceride, LDL and VLDL and increase in HDL. From the result it was concluded that the ethanolic root extract of Limonia acidissima exhibit antihyperlipidemic activitsengt@rediffmail.comResearch522015Limonia acidissima,Hyperlipidemia,AtorvastatinAnebaracy V,Geethavani B,Balamuruganvelu S,Sangamithra V,Shree Lakshmidevi S,Jaikumar SDepartment of Physiology, 2 Department of Microbiology, Sri Lakshmi Narayanan Institute of Medical Sciences, Pondicherry, India.,Department of Microbiology, Sri Lakshmi Narayanan Institute of Medical Sciences, Pondicherry, India,Department of Microbiology, Sri Lakshmi Narayanan Institute of Medical Sciences, Pondicherry, India,Madha Medical College Hospital & Research Institute, Thandalam, Kovur, Chennai, Tamilnadu, India,Madha Medical College Hospital & Research Institute, Thandalam, Kovur, Chennai, Tamilnadu, India,Department of Pharmacology, Sri Lakshmi Narayanan Institute of Medical Sciences, Pondicherry, India