74ANTIDIARRHOEAL ACTIVITY OF AQUEOUS LEAF EXTRACT OF XANTHIUM STRUMARIUM ON CASTOR OIL INDUCED DIARRHEA IN RATSThe present study was conducted to evaluate the antidiarrhoeal activity of aqueous leaf extract of Xanthium strumarium on castor oil induced diarrhea in rats. The test drugs Xanthium strumarium extract at a dose of 250 & 500 mg/kg and reference standard loperamide at a dose of 3 mg /kg were administered orally. After 60 min of test drug administration, the animals received 1ml of castor oil orally and the frequency of defecation and the weight of faecal material was noted up to 4 h and compared to control.sengt@rediffmail.comResearch512015Xanthium strumarium,Antidiarrhoeal activity,LoperamideShreelakshmidevi Singaravelu,Abilash Sasidharan Nair Chandrakumari,Premlal KR,Balamuruganvelu S,Geethavani B,Jaikumar SMadha Medical College & Research Institute, Thandalam, Kovur, Chennai, Tamilnadu, India.,Madha Medical College & Research Institute, Thandalam, Kovur, Chennai, Tamilnadu, India.,Division of Oral Pathology, Rajah Muthiah Dental College & Hospital, Annamalai University, Chidambaram, Tamilnadu, India,Department of Microbiology, Sri Lakshmi Narayanan Institute of Medical Sciences, Pondicherry, India,Department of Microbiology, Sri Lakshmi Narayanan Institute of Medical Sciences, Pondicherry, India,Department of Pharmacology, Sri Lakshmi Narayanan Institute of Medical Sciences, Pondicherry, India