153BREAKING THE CYCLE: A FRESH PERSPECTIVE ON DIABETIC FOOT ULCERSDiabetic Foot Ulcers (DFUs are among the most debilitating complications associated with diabetes mellitus, significantly affecting patients’ quality of life and imposing a considerable burden on healthcare systems. DFUs result from a complex interplay of neuropathy, peripheral vascular disease, immune dysfunction, and poor glycemic control, all of which contribute to delayed wound healing and a high risk of infection. With a global prevalence ranging from 4% to 27%, DFUs are responsible for over half of all non-traumatic lower limb amputations worldwide. The situation is particularly severe in countries with a high number of undiagnosed diabetes cases, such as Indonesia, where mortality and amputation rates due to DFUs remain alarmingly high. This paper provides a comprehensive overview of the pathophysiology, microbiology, classification, and complications of DFUs, highlighting the need for early intervention, multidisciplinary care, and increased awareness to prevent long-term consequences.mpharm76@gmail.comResearch1512025Diabetic Foot Ulcer (DFU), Neuropathy, Peripheral Vascular Disease (PVD), HyperglycemiaDr. Sethuramani A, Sebatini Sinsi A, Gunamathi G, Vinothini M, Punitha M,Sedhulakshmi KAssistant Professor, Department of Pharmacognosy, College of Pharmacy, Madurai Medical College, Madurai, Tamil Nadu, India,Department of Pharmacognosy, College of Pharmacy, Madurai Medical College, Madurai, Tamil Nadu, India.,Department of Pharmacognosy, College of Pharmacy, Madurai Medical College, Madurai, Tamil Nadu, India.