135A SYSTEMIC REVIEW ON HERBS SHOWING NEUROPROTECTIVE EFFECTS AGAINST ALZHEIMER’S DISEASEMemory loss, personality changes, and decline in cognitive function were characteristic of Alzheimer’s disease (AD), a multifactorial, progressive, neurodegenerative disease. A number of factors may contribute to AD progression, including lifestyle, diet, environment, and genetics, although the exact cause of AD remains unclear. There had been two main hypotheses suggested as causes of AD, the cholinergic hypothesis and the amyloid hypothesis. Furthermore, vascular disease, infections, and environmental factors play a role in the disease, including age, genetic factors, head injuries, and genetic factors. In the past decade, more than two hundred promising drug candidates have failed clinical trials, including that the disease and its causes may be extremely complicated. In addition to being complementary and alternative interventions, medicinal plants and herbal remedies were also valuable resources for developing drug candidates for Alzheimer’s disease. An overview of herbal supplements that were anti-inflammatory, anti-oxidative, and cognitively enhancing was provided in this article. Cognitive decline associated with AD can be prevented and treated using medicinal plants. The aim was to identify safe and effective small molecules for AD using these medicinal plants in drug discovery programssubhasree1811@gmail.comResearch1312023Alzheimer’s disease, medicinal herbs, Withania somnifera, Ginkgo biloba, Saffron, Shankhpushpi, Brahmi.Subhasree B S,Bala subramaniyam P N,Satheeshkumar KAssistant Professor, Department of Pharmacognosy, Arulmigu Kalasalingam College of Pharmacy, Krishnan Kovil, Tamilnadu, India,Assistant Professor, Department of Pharmacognosy, Swamy Vivekananda College of Pharmacy, Elayampalayam, Tiruchengode, Tamilnadu, India,Assistant Professor, Department of Pharmacognosy, KG College of Pharmacy and Research Institute, Villupuram, Tamilnadu, India