111NOCHI KUDINEER AN AGE OLD MEDICINE FOR FEBRILE RESPONSEFever is also known as pyrexia and febrile response. It is defined as having a temperature above the normal range due to an increase in the body temperature set point. A fever can be an only symptom in variety of medical conditions ranging from simple to potentially serious. It can be due to viral, bacterial and parasitic infections, systemic conditions, side effects of medication and even cancer. Fever is one of the most common medical signs. About 30% in children and 75% in adults who visit healthcare centers for fever. In the event of antibiotic resistance to infections, epidemic and endemic outbreak threat of infecti ons particularly of viral like ebola, dengue, chikungunya and unknown cause, an alternative, safer, newer moiety of antipyretics effective, in need. Microbes such as bacteria, viral, fungi and parasites adapt to their environment and change their ways tha t ensure their survival. The microbes thrive by means of mutation and carrying resistance genes and remain dominant throughout their span. In Siddha system of medicine, plethoras of herbs and their formulations are used to treat fever and its related illnesses. Here, review of commonly used antipyretic formulation Nochi kudineer are put forth for assured management of infectious fever.gopalveni@yahoo.comReview712017Pyrexia,Antipyretic,Siddha system of medicine,Nochi kudineerG.Lalithambigai,G.Prakash Yoganandam,V.GopalDepartment of Pharmacognosy, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, (A Govt. of Puducherry Institution), Puducherry, India,Department of Pharmacognosy, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, (A Govt. of Puducherry Institution), Puducherry, India,Department of Pharmacognosy, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, (A Govt. of Puducherry Institution), Puducherry, India